Yodoprofilaxis, 65 años después suenan las voces del pasado / Iodine prophylaxis, voices from the past after 65 years

En el año 1953, el Dr. Felipe Rodríguez Moreno se incorpora para continuar el trabajo sobre endemia bociosa de la escuela de Granada, liderada por el Dr. Ortiz de Landázuri. En ese paisaje descubre una alta prevalencia de bocio (62% en mujeres), que se relacionaba con el tipo de dieta consumida, de tal forma que los más desfavorecidos tenían una prevalencia de bocio aún mayor. Así mismo, se encuentra una relación familiar en cuanto al bocio, de manera que los sujetos con bocio normalmente tienen un familiar en primer grado también afectado. El agua de bebida es pobre en yodo de forma generalizada, por lo que no hay diferencias significativas en la prevalencia de bocio según la fuente de la que se surtan los paisanos. Solo se encontraron dos mujeres con cretinismo y dos varones afectados de «idiocia». Por ello, cabe pensar que se trata de bocios normofuncionantes. Tras iniciar yodoprofilaxis con sal yodada en Güejar Sierra, se produce un descenso de la prevalencia de bocio de un 53% a un 13% entre los años 1953-1958 (AU)

In 1953, Dr. Felipe Rodríguez Moreno joined the Granada Research Group on Endemic Goiter, which was led by Dr. Ortiz de Landázuri. A high goiter prevalence (62% in women) was found out within the area, and that prevalence was observed to be related to the dietary habits of the time, being the most disadvantaged those who were showing a greater prevalence. A relationship between the high goiter prevalence and the family of the subjects with goiter was also found out, as they usually had a first-degree relative with affection. Iodine content of drinking water was poor throughout the area, so the prevalence was not significantly different between individuals who drank from different water sources. There were only two females with cretinism and two males affected by «idiocy», so the goiters were probably euthyroid. After introducing iodine prophylaxis with iodized salt in Güejar-Sierra, prevalence decreased from 53% to 13% between 1953 and 1958 (AU)

[A century since the publication of Grossich's paper in Zentralblatt für Chirurgie--an innovation in the field of antisepsis]. / Hundert Jahre seit der Veröffentlichung von Grossichs Werk in Zentralblatt für Chirurgie - Eine Innovation im Bereich der Antisepsis.

This review recalls the first presentation of a modified method for the use of iodine tincture in preoperative disinfection of skin and minor injuries by the Rijeka physician Antonio Grossich (1849-1926), which was published in "Zentralblatt für Chirurgie" 100 years ago. It did not have to wait long before it received acclaim from 20 other medical journals, and in 1909, from the audience at the International Surgery Congress held in Budapest for an extended presentation on the subject. In the following 2 years, surgeons all over the world published their experiences with this optimised technique in over a hundred journals. Doctor Grossich put these articles together and published them with his commentary in 1911 in a monograph entitled "Meine Präparationsmethode des Operationsfelds mittels Jodtinktur" (English: "My personal approach for the preparation of the surgical field using iodine tincture"). Although iodine tincture was also used by other physicians and surgeons at that time, Grossich optimised the method for its use, and he was the first to publish his experience in surgical practice.

[Lipiodol therapeutic indications from 1901 to 1930]. / Les usages therapeutiques du lipiodol, seule "huile iodee vraie", entre 1901 et 1930.

Iodine and iodide used to be very successful drugs, sometimes at massive doses. Highly iodinated oil such as lipiodol from Lafay discovered in 1901 were part of expanding the therapeutic use of iodine for various pathologies such as syphilis, cardiovascular and respiratory diseases, leprosy, goiter... The present publication reviews unpublished documents and publications from 1901 to 1930 on lipiodol to give an overview of therapeutic indications for this agent and the rationale behind it. In some areas such as asthma, iodide was still in use until the eighties. Prevention and treatment of endemic goiter is the only remaining domain for the therapeutic usage of lipiodol. It is the only reason why this product is on the WHO essential drugs list.